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Ramezani, Meraj†, Marcus M. Wilkes†, Tapojyoti Das, David Holowka, David Eliezer*, Barbara Baird*:  Regulation of Exocytosis and Mitochondrial Relocalization by Alpha-Synuclein in a Mammalian Cell Model.  Submitted to bioRχiv . (2018) (DOI) († – co-first authors) (* – co-corresponding authors)

Chylek, Lily A., David A. Holowka, Barbara A. Baird, William S. Hlavacek: Quantitative modeling of mast cell signaling.  In Systems Immunology: An Introduction to Modeling Methods for Scientists (Jayajit Das, Ciriyam Jayaprakash, Editors), CRC Press, Boca Raton, FL, Ch. 13, pp 213-226.

Holowka, David, Kankanit Thanapuasuwan, Barbara Baird: Short chain ceramides disrupt immunoreceptor signaling by inhibiting segregation of Lo from Ld Plasma membrane components.  Biology Open 7(9), 034702-1-9 (2018).  (DOI)

Mitra, Eshan D., Samuel C. Whitehead, David A. Holowka, Barbara A. Baird* and James P. Sethna*: Computation of a Theoretical Membrane Phase Diagram, and the Role of Phase in Lipid Raft-Mediated Protein Organization.  J. Phys. Chem. B 122(13), 3500-3513 (2018). (DOI) (* – co-corresponding authors)

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Harmon, Brooke, Lily A. Chylek, Yanli Liu, Eshan D. Mitra, Avanika Mahajan, Edwin A. Saada, Benjamin R. Schudel, David A. Holowka, Barbara A. Baird, Bridget S. Wilson, William S. Hlavacek and Anup K. Singh: Timescale Separation of Positive and Negative Signaling Creates History-Dependent Responses to IgE Receptor Stimulation.  Scientific Reports 7(1): 15586-1-14 (2017). (DOI)

Wakefield, Devin L., David Holowka and Barbara Baird: The FcεRI Signaling Cascade and Integrin Trafficking Converge at Patterned Ligand Surfaces.  Mol. Biol. Cell 28(23): 3383-3396 (2017). (DOI)

Korzeniowski, Marek K., Eva Wisniewski, Barbara Baird, David Holowka and Tamas Balla: Molecular anatomy of the early events in STIM1 activation; oligomerization or conformational change ?  J. Cell Sci. 130(17): 2821-2832. (DOI)

Holowka, D. and B. Baird: Mechanisms of epidermal growth factor receptor signaling as characterized by patterned ligand activation and mutational analysis.  Biochimica et Biophysica Acta 1859(Issue 9, Part A): 1430-1435 (2017). (DOI)

Sun, C., D.A. Holowka, B.A. Baird and W.R. Dichtel: Beyond Media Composition: Cell Plasma Membrane Disruptions by Graphene Oxide.  Chem 2(3): 324-325 (2017). (DOI)

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Shelby, S.A., S.L. Veatch, D.A. Holowka and B.A. Baird: Functional nanoscale coupling of Lyn kinase with IgE-FcεRI is restricted by the actin cytoskeleton in early antigen-stimulated signaling. Mol. Biol. Cell 27(22): 3645-3658 (2016). (DOI)

Sun, C., D.L. Wakefield, Y. Han, D.A. Muller, D.A. Holowka, B.A. Baird and W.R. Dichtel: Graphene Oxide Nanosheets Stimulate Ruffling and Shedding of Mammalian Cell Plasma Membranes. Chem 1(2): 273-286 (2016). (DOI)

Wilson, J.D., S.A. Shelby, D. Holowka and B. Baird: Rab11 Regulates the Mast Cell Exocytic Response.  Traffic 17(9), 1027-1041 (2016). (DOI)

Holowka, D. and B. Baird: Roles for lipid heterogeneity in immunoreceptor signaling.  Biochimica et Biophysica Acta 1861(8), 830-836 (2016). (DOI)

Korzeniowski, M.K., B. Baird and D. Holowka: STIM1 activation is regulated by a 14 amino acid sequence adjacent to the CRAC activation domain.  AIMS Biophysics 3(1), 99-118 (2016). (DOI)

Holowka, D., M. Wilkes, C. Stefan and B. Baird: Roles for Ca2+ mobilization and its regulation in mast cell functions:  recent progress.  Biochem. Soc. Trans. 44(2), 505-509 (2016). (DOI)

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Jayant, K., A. Singhai, Y. Cao, J.B. Phelps, M. LIndau, D.A. Holowka, B.A. Baird and E.C. Kan: Non-Faradaic Electrochemical Detection of Exocytosis from Mast and Chromaffin Cells Using Floating-Gate MOS Transistors.  Scientific Reports 5, 18477 (2015). (DOI)

Bryant, K.L., B. Baird and D. Holowka: A Novel Fluorescence-based Biosynthetic Trafficking Method Provides Pharmacologic Evidence that Pl4-Kinase IIIalpha is Important for Protein Trafficking from the Endoplasmic Reticulum to the Plasma Membrane.  BMC Cell Biology 16(5), 1-26 (2015). (DOI)

Holowka, D. and B. Baird:  Nanodomains in Early and Later Phases of FcεRI Signaling.  Essays in Biochemistry: Membrane Nanodomains, Vol. 57, 147-163 (2015). (DOI)

Cohen, R., D. Holowka and B. Baird:  Real-time imaging of Ca2+ mobilization and degranulation in mast cells.  Methods in Molecular Biology 1220 (Mast Cells: Methods and Protocols, 2nd ed.), Part IV, Ch. 22, pp. 347-363 (2015). (DOI)

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Singhai, A., D.L. Wakefield, K.L. Bryant, S.R. Hammes, D. Holowka and B. Baird:  Spatially Defined EFG Receptor Activation Reveals an F-Actin-Dependent Phospho-Erk Signaling Complex.  Biophys. J. 107(11), 2639-2651 (2014). (DOI)

Kelly, C.V., D.L. Wakefield, D.A. Holowka, H.G. Craighead and B.A. Baird:  Near-Field Fluorescence Cross-Correlation Spectroscopy on Planar Membrane.  ACS Nano 8(7), 7392-7404 (2014). (DOI)

Wilkes, M.M., J.D. Wilson, B. Baird and D. Holowka:  Activation of Cdc42 is Necessary for Sustained Oscillations of Ca2+ and PIP2 Stimulated by Antigen in RBL Mast Cells.  Biology Open 3(8), 700-710  (2014). (DOI)

Holowka, D., M.K. Korzeniowski, K.L. Bryant and B. Baird:  Polyunsaturated fatty acids inhibit stimulated coupling between the ER Ca2+ sensor STIM1 and the Ca2+ channel protein Orai1 in a process that correlates with inhibition of stimulated STIM1 oligomerization.  Biochim. Biophys. Acta 1841(8): 1210-1216 (2014). (DOI)

Chylek, L.A., D.A. Holowka, B.A. Baird and W.S. Hlavacek:  An interaction library for the FcεRI signaling network.  Front. Immunol. 5: 172 (2014). (DOI)

Olubi, O., D. Gadi, B. Sannigrahi, M. Williams, B. Baird and I. Khan:  Fabrication of electroactive composite nanofibers of functionalized polymer and CNT capable of specifically binding with the IgE (Immunoglobulin E) antibody.  Surf. Interface Anal. 46(4): 237-242 (2014). (DOI)

Welch, M.E., N.L. Ritzert, H. Chen, N.L. Smith, M.E. Tague, Y. Xu, B.A. Baird, H.D. Abruña and C.K. Ober: Generalized Platform for Antibody Detection using the Antibody Catalyzed Water Oxidation Pathway.  J. Am. Chem. Soc. 136(5): 1879-1883, 2014. (DOI)

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Shelby, S.A., D. Holowka, B. Baird and S.L. Veatch:  Distinct Stages of Stimulated FcεRI Receptor Clustering and Immobilization Are Identified through Superresolution Imaging.  Biophys. J. 105(10): 2343-2354, 2013. (DOI)

Bryant, K.L., M.A. Antonyak, R.A. Cerione, B. Baird and D. Holowka:  Mutations in the Polybasic Juxtamembrane Sequence of Both Plasma Membrane- and Endoplasmic Reticulum-localized Epidermal Growth Factor Receptors Confer Ligand-independent Cell Transformation.  J. Biol. Chem. 288(48): 34930-34942, 2013. (DOI)

Smith, N.L., D.S. Abi Abdallah, B.A. Butcher, E.Y. Denkers, B. Baird and D. Holowka:  Toxoplasma gondii Inhibits Mast Cell Degranulation by Suppressing Phospholipase Cg–mediated Ca2+ Mobilization.  Front. Microbiol. 4: 179, 2013. (DOI)

Midthun, K.M., P.G. Taylor, C. Newby, M. Chatzichristidi, P.S. Petrou, J.-K. Lee, S.E. Kakabakos, B.A. Baird and C.K. Ober:  Orthogonal Patterning of Multiple Biomolecules Using an Organic Fluorinated Resist and Imprint Lithography.  Biomacromolecules 14(4): 993-1002, 2013. (DOI)

Santos, M.deS., R.M.Z.G. Naal, B. Baird and D. Holowka: Inhibitors of PI(4,5)P2 Synthesis Reveal Dynamic Regulation of IgE Receptor Signaling by Phosphoinositides in RBL Mast Cells.  Mol. Pharmacol. 83(4): 793-804, 2013. (DOI)

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Doss, J., O. Olubi, B. Sannigrahi, M.D. Williams, D. Gadi, B. Baird and I. Khan:  Procedure for Fabricating Biofunctional Nanofibers.  J. Vis. Exp. 67: e4135, 2012. (DOI)

Welch, M. Elizabeth, Y. Xu, H. Chen, N. Smith, M.E. Tague, H.D. Abruña, B. Baird and C.K. Ober: Polymer Brushes as Functional, Patterned Surfaces for Nanobiotechnology.  J. Photopolym. Sci. Technol. 25(1): 53-56, 2012. (DOI)

Lee, J., S.L. Veatch, B. Baird and D. Holowka: Molecular Mechanisms of Spontaneous and Directed Mast Cell Motility.  J. Leukoc. Biol. 92(5): 1029-1041, 2012. (DOI)

Holowka, D., N. Calloway, R. Cohen, D. Gadi, J. Lee, N.L. Smith and B. Baird: Roles for Ca2+ Mobilization and its Regulation in Mast Cell Functions.  Front. Immunol. 3: 104, 2012. (DOI)

Reuven, D., D. Sil, B. Sannigrahi, X-Q Wang, B. Baird and I.M. Khan: Archetypical Conductive Polymer Structure for Specific Interaction with Proteins.  J. Macromol. Sci. (Part A: Pure & Appl. Chem.) 49(4): 330-338, 2012. (DOI)

Veatch, S., E. Chiang, P. Sengupta, D. Holowka and B. Baird: Quantitative Nano-Scale Analysis of IgE-FcεRI Clustering and Coupling to Early Signaling Proteins.  J. Phys. Chem. B 116(23): 6923-6935, 2012. (DOI)

Veatch, S.L., B.B. Machta, S.A. Shelby, E.N. Chiang, D.A. Holowka and B.A. Baird: Correlation Functions Quantify Super-resolution Images and Estimate Apparent Clustering Due to Over-counting.  PLoS One 7(2): e31457, 2012. (DOI)

Cohen, R., K. Corwith, D. Holowka and B. Baird: Spatiotemporal Resolution of Mast Cell Granule Exocytosis Reveals Correlation with Ca2+ Wave Initiation.  J. Cell Sci. 25(12): 2986-2994, 2012. (DOI)

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Gadi, D., A. Wagenknecht-Wiesner, D. Holowka and B. Baird: Sequestration of Phosphoinositides by Mutated MARCKS Effector Domain Inhibits Stimulated Ca2+ Mobilization and Degranulation in Mast Cells.  Mol. Biol. Cell 22(24): 4908-4917, 2011. (DOI)

Chiang, Y-W, A.J. Costa-Filho, B.A. Baird and J.H. Freed: 2D-ELDOR Study of Heterogeneity and Domain Structure Changes in Plasma Membrane Vesicles Upon Crosslinking of IgE Receptors.  J. Phys. Chem. B 115(35): 10462-10469, 2011. (DOI)

Calloway, N., T. Owens, K. Corwith, W. Rodgers, D. Holowka and B. Baird: Stimulated Association of STIM1 and Orai1 is Regulated by the Balance of PtdIns(4,5)P2 between Distinct Membrane Pools.  J. Cell Sci. 124(15): 2602-2610, 2011. (DOI)

Torres, A.J., D. Holowka and B.A. Baird: Micropatterned Ligand Arrays to Study Spatial Regulation in Fc Receptor Signaling. In Methods in Molecular Biology, Vol. 748 (Immune Receptors: Methods and Protocols, Eds., J.P. Rast and J.W.D. Booth), Chap. 14, pp. 195-207, 2011.

Chiang, E.N., R. Dong, C.K. Ober and B.A. Baird: Cellular Responses to Patterned Poly(acrylic acid) Brushes.  Langmuir 27(11): 7016-7023, 2011. (DOI)

Kelly, C.V., B.A. Baird and H.G. Craighead: An Array of Planar Apertures for Near-Field Fluorescence Correlation Spectroscopy.  Biophys. J. 100(7): L34-L36, 2011. (DOI)

Brust-Mascher, I., B.A. Baird and W.W. Webb: Response to Kang et al.  Biophys. J. 100(3): 793-794, 2011. (DOI)

Suteewong, T., H. Sai, R. Cohen, S. Wang, M. Bradbury, B. Baird, S. Gruner and U. Wiesner: Highly Aminated Mesoporous Silica Nanoparticles with Cubic Pore Structure.  J. Am. Chem. Soc. 133(2): 172-175, 2011. (DOI)

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Smith, N.L., S. Hammond, D. Gadi, A. Wagenknecht-Wiesner, B. Baird and D. Holowka: Sphingosine derivatives inhibit cell signaling by electrostatically neutralizing polyphosphoinositides at the plasma membrane.  Self/Nonself 1(2): 133-143, 2010. (DOI)

Calloway, N., D. Holowka and B. Baird: A Basic Sequence in STIM1 Promotes Ca2+ Influx by Interacting with the C-Terminal Acidic Coiled-Coil of Orai1.  Biochemistry 49(6): 1067-1071, 2010. (DOI)

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Cohen, R., A. Torres, H-T Ma, D. Holowka and B. Baird: Ca2+ Waves Initiate Antigen-Stimulated Ca2+ Responses in Mast Cells.  J. Immunol. 183(10): 6478-6488, 2009. (DOI)

Haka, A.S., I. Grosheva, E. Chiang, A.R. Buxbaum, B.A. Baird, L.M. Pierini and F.R. Maxfield: Macrophages Create an Acidic Extracellular Hydrolytic Compartment to Digest Aggregated Lipoproteins.  Mol. Biol. Cell 20(23): 4932-4940, 2009. (DOI)

Rastogi, A., S. Nad, M. Tanaka, N. Da Mota, M. Tague, B.A. Baird, H.D. Abruña and C.K. Ober: Preventing Non-Specific Adsorption on Polymer Brush Covered Gold Electrodes Using a Modified ATRP Initiator.  Biomacromolecules 10(10): 2750-2758, 2009. (DOI)

Han, X., N.L. Smith, D. Sil, D.A. Holowka, F.W. McLafferty and B.A. Baird: IgE Receptor-Mediated Alteration of Membrane-Cytoskeleton Interactions Revealed by Mass Spectrometric Analysis of Detergent-Resistant Membranes.  Biochemistry 48(27): 6540-6550, 2009. (DOI)

Hammond, S., A. Wagenknecht-Wiesner, S.L. Veatch, D. Holowka and B. Baird: Roles for SH2 and SH3 domains in Lyn kinase association with activated FcεRI in RBL mast cells revealed by patterned surface analysis.  J. Struct. Biol. 168(1): 161-167, 2009. (DOI)

Vasudevan, L., A. Jeromin, L. Volpicelli-Daley, P. De Camilli, D. Holowka and B. Baird: The β- and γ-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells.  J. Cell Sci. 122(14): 2567-2574, 2009. (DOI)

Hammond, S., D. Holowka and B. Baird. Membrane Compartments Related to Signaling and Trafficking in Immune Cells. In Wiley Encyclopedia of Chemical Biology, 4 Volume Set (Ed. T.P. Begley) Wiley InterScience; Vol. 2, pp. 718-728, January 2009.

Calloway, N., M. Vig, J.-P. Kinet, D. Holowka and B. Baird: Molecular Clustering of STIM1 with Orai1/CRACM1 at the Plasma Membrane Depends Dynamically on Depletion of Ca2+ Stores and on Electrostatic Interactions.  Mol. Biol. Cell 20(1): 389-399, 2009. (DOI)

Holowka, D.: Biomembrane liquid-liquid phase separation and detergent resistance: a relationship strengthened.  Biochem. J. 424: e5-6, 2009.

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Torres, A.J., L. Vasudevan, D. Holowka and B. Baird: Focal Adhesion Proteins Connect IgE Receptors to the Cytoskeleton as Revealed by Micropatterned Ligand Arrays.  Proc. Natl. Acad. Sci. 105(45): 17238-17244, 2008. (DOI)

Sannigrahi, B., D. Sil, B. Baird, X.Q. Wang and I.M. Khan. Synthesis and Characterization of α,ω-bi[2,4-dinitrophenyl (DNP)] poly(2-methoxystyrene) Functional Polymers. Initial Evaluation of the Interaction of the Functional Polymers with RBL Mast Cells.  J. Macromol. Sci. (Part A: Pure & Appl. Chem.) 45(8): 664-671, 2008. (DOI)

Veatch, S., P. Cicuta, P. Sengupta, A. Honerkamp-Smith, D. Holowka and B. Baird: Critical Fluctuations in Plasma Membrane Vesicles.  ACS Chem. Biol. 3(5): 287-293, 2008. (DOI)

Torres, A.J., M. Wu, D. Holowka and B. Baird: Nanobiotechnology and Cell Biology: Micro- and Nanofabricated Surfaces to Investigate Receptor-Mediated Signaling.  Annu. Rev. Biophys. 37: 265-288, 2008. (DOI)

Sengupta, P., A. Hammond, D. Holowka and B. Baird: Structural determinants for partitioning of lipids and proteins between coexisting fluid phases in giant plasma membrane vesicles.  Biochim. Biophys. Acta 1778(1): 20-32, 2008. (DOI)

Das, R., E. Baird, S. Allen, B. Baird, D. Holowka and B. Goldstein: Binding Mechanisms of PEGylated Ligands Reveal Multiple Effects of the PEG Scaffold.  Biochemistry 47(3): 1017-1030, 2008. (DOI)

Das, R., S. Hammond, D. Holowka and B. Baird: Real-Time Cross-Correlation Image Analysis of Early Events in IgE Receptor Signaling.  Biophys. J. 94(12): 4996-5008, 2008. (DOI)

Curtis, T., R.M. Naal, C. Batt, J. Tabb and D. Holowka: Development of a mast cell-based biosensor. Biosens. Bioelectron. 23: 1024-1031, 2008.

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Sengupta, P., B. Baird and D. Holowka: Lipid rafts, fluid/fluid phase separation, and their relevance to plasma membrane structure and function.  Semin. Cell & Dev. Biol. 18(5): 583-590, 2007. (DOI)

Dong, R., S. Krishnan, B.A. Baird, M. Lindau and C.K. Ober: Patterned Biofunctional Poly(acrylic acid) Brushes on Silicon Surfaces.  Biomacromolecules 8(10): 3082-3092, 2007. (DOI)

Sil, D., J.B. Lee, D. Luo, D. Holowka and B. Baird: Trivalent Ligands with Rigid DNA Spacers Reveal Structural Signaling in RBL Mast Cells.  ACS Chem. Biol. 2(10): 674-684, 2007. (DOI)

Holowka, D., D. Sil, C. Torigoe and B. Baird: Insights into immunoglobulin E receptor signaling from structurally defined ligands.  Immunol. Rev. 217(1): 269-279, 2007. (DOI)

Moran-Mirabal, J.M., A.J. Torres, K.T. Samiee, B.A. Baird and H.G. Craighead: Cell investigation of nanostructures: zero-mode waveguides for plasma membrane studies with single molecule resolution.  Nanotechnology 18(19): 195101-195111, 2007. (DOI)

Baumgart, T., A.T. Hammond, P. Sengupta, S.T. Hess, D.A. Holowka, B.A. Baird and W.W. Webb: Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesicles. Proc. Natl. Acad. Sci. 104(9): 3165-3170, 2007. (DOI)

Sengupta, P., D. Holowka and B. Baird: Fluorescence Resonance Energy Transfer between Lipid Probes Detects Nanoscopic Heterogeneity in the Plasma Membrane of Live Cells.  Biophys. J. 92(10): 3564-3574, 2007. (DOI)

Wu, M., T. Baumgart, S. Hammond, D. Holowka and B. Baird: Differential targeting of secretory lysosomes and recycling endosomes in mast cells revealed by patterned antigen arrays.  J. Cell Sci. 120(17): 3147-3154, 2007. (DOI)

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Senaratne, W., K. Takada, R. Das, J. Cohen, B. Baird, H.D. Abruña and C.K. Ober: Dinitrophenyl Ligand Substrates and Their Application to Immunosensors.  Biosens. Bioelectron. 22(1): 63-70, 2006. (DOI)

Burns A., P. Sengupta, T. Zedayko, B. Baird and U. Wiesner: Core-Shell Fluorescent Silica Nanoparticles for Chemical Sensing: Moving towards Single Particle Laboratories.  Small 2(6): 723-726, 2006. (DOI)

Swamy, M.J., L. Ciani, M. Ge, D. Holowka, B. Baird and J.H. Freed: Coexisting domains in the plasma membranes of live cells characterized by spin label ESR.  Biophys. J. 90(12): 4452-4465, 2006. (DOI)

Senaratne, W., P. Sengupta, V. Jakubek, D. Holowka, C.K. Ober and B. Baird: Functionalized Surface Arrays for Spatial Targeting of Immune Cell Signaling.  J. Am. Chem. Soc. 128(17): 5594-5595, 2006. (DOI)

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Larson, D.R., J.A. Gosse, D. Holowka, B. Baird and W.W. Webb: Temporally Resolved Interactions Between Antigen-stimulated IgE Receptors and Lyn Kinase on Living Cells.  J. Cell Sci. 171(3): 527-536, 2005. (DOI)

Joralemon, M.J., N.L. Smith, D. Holowka, B. Baird and K.L. Wooley: Antigen-decorated Shell Crosslinked Nanoparticles: Synthesis, Characterization and Antibody Interactions.  Bioconjugate Chem. 16(5): 1246-1256, 2005. (DOI)

Holowka, D., J.A. Gosse, A.T. Hammond, X. Han, P. Sengupta, N.L. Smith, A. Wagenknecht-Wiesner, M. Wu, R.M. Young and B. Baird: Lipid Segregation and IgE Receptor Signaling: A Decade of Progress.  Biophys. Biochim. Acta. 1746(3): 252-259, 2005. (DOI)

Gosse, J.A., A. Wagenknecht-Wiesner, D. Holowka and B. Baird: Transmembrane Sequences are Determinants of Immunoreceptor Signaling.  J. Immunol. 175: 2123-2131, 2005.

Senaratne, W., C. Harnett, P. Sengupta, B. Baird, H.G. Craighead and C.K. Ober: Molecular Templates for Bio-specific Recognition by Low-Energy Electron Beam Lithography. NanoBiotechnology 1: 23-34, 2005. (DOI)

Hammond, A.T., F.A. Heberle, T. Baumgart, D. Holowka, B. Baird and G.W. Feigenson: Crosslinking a lipid raft component triggers liquid ordered-liquid disordered phase separation in model plasma membranes.  Proc. Natl. Acad. Sci. 102(18): 6320-6325, 2005. (DOI)

Andruzzi, L., W. Senaratne, E.D. Sheets, B. Ilic, A. Hexemer, E.J. Kramer, B.A. Baird and C.K. Ober: Oligo(ethylene glycol) containing polymer brushes as Bio-selective surface.  Langmuir 21(6): 2495-2504, 2005. (DOI)

Ow, H., D.R. Larson, M. Srivastava, B.A. Baird, W.W. Webb and U. Wiesner: Core-Shell Fluorescent Silica Nanoparticles for Biological Imaging.  Nano Letters 5: 113-117, 2005. (DOI)

Edel, J.B., M. Wu, B. Baird and H. Craighead: High Spatial Resolution Observation of Single Molecule Dynamics in Living Cell Membranes.  Biophys. J. 88(6): L43-5, 2005. (DOI)

Young, R.M., X. Zheng, D. Holowka and B. Baird: Reconstitution of Regulated Phosphorylation of FcεRI by a Lipid Raft-excluded Protein-tyrosine Phosphatase.  J. Biol. Chem. 280(2): 1230-1235, 2005. (DOI)

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Naal, R.M.Z.G., J. Tabb, D. Holowka and B. Baird: In situ measurement of degranulation as a biosensor based on RBL-2H3 mast cells.  Biosens. Bioelectron. 20(4):791-796, 2004. (DOI)

Wu, M., D. Holowka, H.G. Craighead and B. Baird: Visualization of Plasma Membrane Compartmentalization with Patterned Lipid Bilayers.  Proc. Natl. Acad. Sci. 101(38): 13798-13803, 2004. (DOI)

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Baird, E.J., D. Holowka, G.W. Coates and B. Baird: Highly Effective Poly(Ethylene Glycol) Ligands for Specific Inhibition of Cell Activation by IgE Receptors.  Biochemistry 42(44): 12739-12748, 2003. (DOI)

Pyenta, P., P. Schwille, W.W. Webb, D. Holowka and B. Baird: Lateral Diffusion of Membrane Lipid-Anchored Probes Before and After Aggregation of Cell Surface IgE-Receptors.  J. Phys. Chem. A 107(40): 8310-8318, 2003. (DOI)

Ge, M., A. Gidwani, H.A. Brown, D. Holowka, B. Baird and J.H. Freed: Ordered and Disordered Phases Coexist in Plasma Membrane Vesicles of RBL-2H3 Mast Cells. An ESR Study.  Biophys. J. 85(2): 1278-1288, 2003. (DOI)

Gidwani, A., H.A. Brown, D. Holowka and B. Baird: Disruption of lipid order by short chain ceramides correlates with inhibition of phospholipase D1 and downstream signaling by FcεRI.  J. Cell Sci. 116(15): 3177-3187, 2003. (DOI)

Young, R.M., D. Holowka and and B. Baird: A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation.  J. Biol. Chem. 278(23): 20746-20752, 2003. (DOI)

Naal, R.M.Z.G., E.P. Holowka, B. Baird and D. Holowka: Antigen-Stimulated Trafficking from the Recycling Compartment to the Plasma Membrane in RBL Mast Cells.  Traffic 4(3): 190-200, 2003. (DOI)

Orth, R., M. Wu, D.A. Holowka, H.G. Craighead and B.A. Baird: Mast Cell Activation on Patterned Lipid Bilayers of Subcellular Dimensions.  Langmuir 19(5): 1599-1605, 2003. (DOI)

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Paar, J.M., N. Harris, D. Holowka and B. Baird: Bivalent Ligands with Rigid Double-Stranded DNA Spacers Reveal Structural Constraints to Signaling by FcεRI.  J. Immunol. 169(2): 856-864, 2002.

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Gidwani, A., D. Holowka and B. Baird: Fluorescence Anisotropy Measurements of Lipid Order in Plasma Membranes and Lipid Rafts from RBL-2H3 Mast Cells.  Biochemistry 40(41): 12422-12429, 2001. (DOI)

Pyenta, P.S., D. Holowka and B. Baird: Cross-Correlation Analysis of Inner Leaflet-anchored GFP Co-redistributed with IgE Receptors and Outer Leaflet Lipid Raft Components.  Biophys. J. 80(5): 2120-2132, 2001. (DOI)

Hong-Geller, E., D. Holowka, R.P. Siraganian, B. Baird and R. Cerione: Activated Cdc42/Rac reconstitutes FcεRI-mediated Ca2+ and degranulation in mutant mast cells.  Proc. Natl. Acad. Sci. 98(3): 1154-1159, 2001. (DOI)

Holowka, D. and B. Baird: FcεRI as a paradigm for a lipid raft-dependent receptor in hematopoietic cells.  Sem. Immunol. 13(2): 99-105, 2001. (DOI)

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Field, K.A., J.R. Apgar, E. Hong-Geller, R.P. Siraganian, B. Baird and D. Holowka: Mutant RBL mast cells defective in FcepsilonRI signaling and lipid raft biosynthesis are reconstituted by activated rho-family GTPases.  Mol. Biol. Cell 11(10): 3661-3673, 2000. (DOI)

Fridriksson, E.K., A. Beavil, D. Holowka, H.J. Gould, B. Baird and F.W. McLafferty: Heterogeneous glycosylation of immunoglobulin E constructs characterized by top down high-resolution 2-D mass spectrometry.  Biochemistry 39(12): 3369-3376, 2000. (DOI)

Holowka, D., E.D. Sheets and B. Baird: Interactions between FcεRI and detergent-resistant membrane domains (rafts) are regulated by the actin cytoskeleton.  J. Cell Sci. 113(6): 1009-1019, 2000.

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Baird, B., E.D. Sheets and D. Holowka: How does the plasma membrane participate in cellular signaling by receptors for immunoglobulin E?  Biophys. Chem. 82(2-3): 109-119, 1999. (DOI)

Sheets, E.D., D. Holowka and B. Baird: Critical role for cholesterol in lyn-mediated tyrosine phosphorylation of FcεRI and their association with detergent-resistant membranes.  J. Cell Biol. 145(4): 877-887, 1999. (DOI)

Fridriksson, E.K., P. Shipkova, E.D. Sheets, D. Holowka, B. Baird and F.W. McLafferty: Quantitative analysis of phospholipids in functionally important membrane domains from RBL-2H3 mast cells using tandem high-resolution mass spectrometry.  Biochemistry 38(25): 8056-8063, 1999. (DOI)

Ge, M., K.A. Field, R. Aneja, D. Holowka, B. Baird and J.H. Freed: ESR characterization of liquid ordered phase of detergent resistant membranes from RBL-2H3 Cells.  Biophys. J. 77(2): 925-933, 1999. (DOI)

Fridriksson, E.K., B. Baird and F.W. McLafferty: Electrospray mass spectra from protein electroeluted from SDS-PAGE Gels.  J. Am. Soc. Mass Spectrom. 10(5): 453-455, 1999. (DOI)

Field, K.A., D. Holowka and B. Baird: Structural aspects of the association of FcεRI with detergent resistant membranes.  J. Biol. Chem. 274(3): 1753-1758, 1999. (DOI)

Guo, C., K.E. Georgiadis, S.K. Dower, D. Holowka and B. Baird: Interleukin 1 (IL-1) causes changes in lateral and rotational mobilities of IL-1 type 2 receptors.  Biochemistry 38(5): 1618-1625, 1999. (DOI)

Sheets, E.D., D. Holowka and B. Baird: Membrane organization in IgE receptor signaling.  Curr. Opin. Chem. Biol. 3(1): 95-99, 1999. (DOI)

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Baird, B., K.A. Field and D. Holowka: IgE receptor signaling utilizes membrane domains.  Biol. Skr. Dan. Vid. Selsk. 49: 147-151, 1998.

Xu, K., R.M. Williams, D. Holowka and B. Baird: Stimulated release of fluorescently-labeled IgE fragments that efficiently accumulate in secretory granules after endocytosis in RBL-2H3 mast cells. J. Cell Sci. 111(16): 2385-2396, 1998.

Field, K.A., D. Holowka and B. Baird: FcεRI signaling in specialized membrane domains. In Signal Transduction in Mast Cells and Basophils  (Eds., E. Razin and J. Rivera) Springer-Verlag, New York; 102-114, 1998.

Xu, K., B. Goldstein, D. Holowka and B. Baird: Kinetics of multivalent antigen DNP-BSA binding to IgE-FcεRI in relationship to stimulated tyrosine phosphorylation of FcεRI.  J. Immunol. 160(7): 3225-3235, 1998.

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Pierini, L.M., N.T. Harris, D. Holowka and B. Baird: Evidence supporting a role for microfilaments in regulating the coupling between poorly dissociable IgE-FcεRI aggregates and downstream signaling pathways.  Biochemistry 36(24): 7447-7456, 1997. (DOI)

Field, K.A., D. Holowka and B. Baird: Compartmentalized activation of the high affinity IgE receptor within membrane domains.  J. Biol. Chem. 272(7): 4276-4280, 1997. (DOI)

Harris, N.T., B. Goldstein, D. Holowka and B. Baird: Altered patterns of tyrosine phosphorylation and Syk activation for sterically restricted cyclic dimers of IgE-FcεRI.  Biochemistry 36(8): 2237-2242, 1997. (DOI)

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Pierini, L.M., D. Holowka and B. Baird: FcεRI-mediated association of 6 mM beads with RBL-2H3 mast cells results in exclusion of signaling proteins from the phagosome and abrogation of normal downstream signaling.  J. Cell Biol. 134(6): 1427-1439, 1996. (DOI)

Feder, T.J., I. Brust-Mascher, J.P. Slattery, B. Baird and W.W. Webb: Constrained Diffusion or Immobile Fraction on Cell Surfaces: a New Interpretation.  Biophys. J. 70(6): 2767-2773, 1996. (DOI)

Subramanian, K., D. Holowka, B. Baird and B. Goldstein: The Fc segment of IgE influences the kinetics of dissociation of a symmetrical bivalent ligand from cyclic dimeric complexes.  Biochemistry 35(17): 5518-5527, 1996. (DOI)

Hashemi, B.B., J.P. Slattery, D. Holowka and B. Baird: Sustained T cell receptor-mediated Ca2+ responses rely on dynamic engagement of receptors.  J. Immunol. 156(10): 3660-3667, 1996.

Holowka, D. and B. Baird: Antigen-mediated IgE receptor aggregation and signaling:  A window on cell surface structure and dynamics.  Annu. Rev. Biophys. Biomol. Struct. 25: 79-112, 1996. (DOI)

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Guo, C., S. Dower, D. Holowka and B. Baird: Fluorescence resonance energy transfer reveals IL-1-dependent aggregation of IL-1 type I receptors that correlates with receptor activation.  J. Biol. Chem. 270(46): 27562-27568, 1995. (DOI)

Field, K.A., D. Holowka and B. Baird: FcεRI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling.  Proc. Natl. Acad. Sci. 92(20): 9201-9205, 1995. (DOI)

Posner, R.G., K. Subramanian, J. Thomas, T. Feder, D. Holowka, B. Baird and B. Goldstein: Simultaneous crosslinking by two non-triggering bivalent ligands causes synergistic signaling of IgE-FcεRI complexes.  J. Immunol. 155(7): 3601-3609, 1995.

Chang, E.-Y., S.-Y. Mao, H. Metzger, D. Holowka and B. Baird: Effects of subunit mutation on the rotational dynamics of FcεRI, the high affinity receptor for IgE, in transfected cells.  Biochemistry 34(18): 6093-6099, 1995. (DOI)

Chang, E.-Y., Y. Zheng, D. Holowka and B. Baird: Alteration of lipid composition modulates FcεRI signaling in RBL-2H3 Cells.  Biochemistry 34(13): 4376-4384, 1995. (DOI)

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Thomas, J.L., D. Holowka, B. Baird and W.W. Webb: Large-scale co-aggregation of fluorescent lipid probes with cell surface proteins.  J. Cell Biol. 125(4): 795-802, 1994. (DOI)

Feder, T.J., E.Y. Chang, D. Holowka and W.W. Webb. Disparate modulation of plasma membrane protein lateral mobility by various cell permeabilizing agents.  J. Cell Physiol. 158: 7-16, 1994.

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Baird, B., Y. Zheng and D. Holowka: Structural mapping of IgE-FcεRI, an immuno-receptor complex. Acc. Chem. Res.  26(8): 428-434, 1993. (DOI)

Weetall, M., D. Holowka and B. Baird: Heterologous desensitization of FcεRI on RBL Cells.  J. Immunol. 150(9): 4072-4083, 1993.

Marano, N., M. Liotta, J.P. Slattery, D. Holowka and B. Baird: FcεRI and the T cell receptor for antigen activate similar signaling pathways in T cell – RBL cell hybrids.  Cellular Signalling 5(2): 155-167, 1993. (DOI)

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Posner, R.G., B. Lee, D.H. Conrad, D. Holowka, B. Baird and B. Goldstein: Aggregation of IgE-receptor complexes on rat basophilic leukemia cells does not change the intrinsic affinity but can alter the kinetics of the ligand-IgE interaction.  Biochemistry 31(23): 5350-5356, 1992. (DOI)

Zheng, Y., B. Shopes, D. Holowka and B. Baird: Dynamic conformations compared for IgE and IgG1 in solution and bound to receptors.  Biochemistry 31(33): 7446-7456, 1992. (DOI)

Holowka, D. and B. Baird: Recent evidence for common signalling mechanisms among immunoreceptors that recognize foreign antigens.  Cellular Signalling 4(4): 339-349, 1992. (DOI)

Myers, J., D. Holowka and B. Baird: Rotational motion of monomeric and dimeric immunoglobulin E-receptor complexes.  Biochemistry 31(2): 567-575, 1992. (DOI)

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Erickson, J., R. Posner, B. Goldstein, D. Holowka and B. Baird: Analysis of ligand binding and crosslinking of receptor in solution and on cell surfaces: Immunoglobulin E as a model system. In Biophysical and Biochemical Aspects of Fluorescence Spectroscopy (Ed. T.G. Dewey) Plenum Press, New York, pp. 169-195, 1991.

Posner, R., J. Erickson, D. Holowka, B. Baird and B. Goldstein: Dissociation kinetics of bivalent hapten – immunoglobulin E aggregates in solution.  Biochemistry 30(9): 2348-2356, 1991. (DOI)

Erickson, J., R.G. Posner, B. Goldstein, D. Holowka and B. Baird: Bivalent ligand dissociation kinetics from receptor-bound immunoglobulin E:  Evidence for a time dependent increase in ligand rebinding at the cell surface.  Biochemistry 30(9): 2357-2363, 1991. (DOI)

Keegan, A., C. Fratazzi, B. Shopes, B. Baird and D. Conrad: Characterization of monoclonal rat anti-mouse IgE antibodies and their use to map the site on mouse IgE that interacts with FcεRI and FcεRII.  Molec. Immunol. 28(10): 1149-1154, 1991. (DOI)

Labrecque, G., D. Holowka and B. Baird: Characterization of increased K+ permeability associated with the stimulation of receptors for immunoglobulin E on rat basophilic cells.  J. Biol. Chem. 266(23): 14912-14917, 1991.

Zheng, Y., B. Shopes, D. Holowka and B. Baird: Conformation of IgE bound to receptor and in solution.  Biochemistry 30(38): 9125-9131, 1991. (DOI)

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Kane, P., D. Holowka and B. Baird: Characterization of model antigens composed of biotinylated haptens bound to avidin.  Immunol. Invest. 19(1): 1-25, 1990. (DOI)

Narasimhan, V., D. Holowka and B. Baird: A guanine nucleotide-binding protein participates in IgE receptor-mediated activation of endogenous and reconstituted phospholipase A2 in a permeabilized cell system.  J. Biol. Chem. 265(3): 1459-1464, 1990.

Holowka, D., T. Wensel and B. Baird: A nanosecond fluorescence depolarization study on the segmental flexibility of receptor-bound IgE.  Biochemistry 29(19): 4607-4612, 1990. (DOI)

Holowka, D. and B. Baird: Structure and function of the high affinity receptor for immunoglobulin E. In Cellular and Molecular Mechanisms of Inflammation: Receptors of Inflammatory Cells, C.C. Cochrane and M. Gimbrone, eds.. Academic Press, Inc., Orlando, FL, pp. 173-197, 1990.

Narasimhan, V., D. Holowka and B. Baird: Microfilaments regulate the rate of exocytosis in rat basophilic leukemia cells.  Biochem. Biophys. Res. Comm. 171(1): 222-229, 1990. (DOI)

Shopes, B., M. Weetall, D. Holowka and B. Baird: Recombinant human IgG1-murine IgE chimeric immunoglobulins: Construction, expression, and binding to human FcεRI and FcεRII.  J. Immunol. 145(11): 3842-3848, 1990.

Weetall, M., B. Shopes, D. Holowka and B. Baird: Mapping the site of interaction between murine IgE and its high affinity receptor with chimeric immunoglobulins.  J. Immunol. 145(11): 3849-3854, 1990.

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